Clinical Case Database / Category: Patient Management

Raised alkaline phosphatase

Publication details

Tim Sparkes, Sandeep Patel, Saran Shantikumar, Ashok Handa
Foundation Years Journal, volume 5, issue 1, p.31 (123Doc Education, London, February 2011)


This case based discussion focuses on the causes and investigation of a raised alkaline phosphatase.

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Tim Sparkes

Foundation Year Doctor
Nuffield Department of Surgical Sciences
John Radcliffe Hospital

Sandeep Patel

Surgical Registrar
Department of Surgery
Wycombe General Hospital
High Wycombe
HP11 2TT

Saran Shantikumar

Academic Clinical Fellow
Nuffield Department of Surgical Sciences
John Radcliffe Hospital

Ashok Handa

Consultant Surgeon and Clinical Tutor
Nuffield Department of Surgical Sciences
John Radcliffe Hospital


1. Maldonado O, Demasi R, Maldonado Y, Taylor M, Troncale F, Vender R. Extremely high levels of alkaline phosphatase in hospitalized patients. J Clin Gastroenterol 1998;27(4):342-5.
2. Clinical Chemistry 6th Edition, Marshall & Bangert
3. Clinical Chemistry and Metabolic Medicine, Crook
4. Clinical laboratory medicine, 2nd edition, Edited by McCatchey
5. Drug-Induced Hepatotoxicity, Mehta, Ozick and Gbadehan, April 26th 2010, Emedicine


Conflict Of Interest

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Financial Statement

The authors of this article have not been paid. The Journal is financed by subscriptions and advertising. The Journal does not receive money from any other sources. The decision to accept or refuse this article for publication was free from financial considerations and was solely the responsibility of the Editorial Panel and Editor-in-Chief.

Patient Consent statement

All pictures and investigations shown in this article are shown with the patients’ consent. We require Authors to maintain patients’ anonymity and to obtain consent to report investigations and pictures involving human subjects when anonymity may be compromised. The Journal follows the Guidelines of the Uniform Requirements for Manuscripts ( The Journal requires in its Guidelines for Authors a statement from Authors that “the subject gave informed consent”.

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When reporting experiments on human subjects, the Journal requires authors to indicate whether the procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the HelsinkiDeclaration of 1975, as revised in 2008.

About the Clinical Cases Database

T​he Foundation Years Clinical Cases Database is​ a selection of 600 peer-reviewed clinical cases in the field of patient safety and clinical practice, specifically focused on the clinical information needs of junior doctors, based around the Foundation Year Curriculum programme (MMC). The cases have been chosen to align with the Foundation Year Curriculum.

The database is fully searchable, or can be browsed by medical specialty. Abstracts can be read free of charge, however a subscription is required in order to read the complete cases.