Video Review Course: Clinical Pharmacology

Studying Clinical Pharmacology

Dr Andrew Webb teaches Clinical Pharmacology

Clinical Pharmacology Chapters

  • Clinical Pharmacology for MRCP 1
  • Clinical pharmacology
  • Main topics
  • Pharmacokinetics
  • PK: absorption
  • Interactions!
  • May be two-way!
  • PK interactions: absorption
  • PK: volume of distribution, Vd
  • PK interactions: displacement
  • Hypoalbuminuria and phenytoin - caution with levels
  • PK: metabolic pathways e.g., paracetamol
  • PK: metabolism First pass metabolism
  • PK: metabolism Zero order kinetics - phenytoin
  • PK: metabolism Low extraction drugs
  • PK: metabolism Zero order kinetics - phenytoin
  • PK: metabolic interactions Liver enzyme inducers: PC BRAS
  • PK: metabolic interactions Liver enzyme inhibitors: GO DEVICES
  • Clinically significant interactions affect drugs with a narrow therapeutic range: WAC STOPS:
  • Recent Issues
  • Statins and CYP3A4 inhibitors
  • Statins and rhabdomyolysis
  • Oral erythromycin and the risk of sudden death from cardiac causes
  • PK: interactions - warfarin
  • Other inhibitor interactions
  • PK: interactions - excretion
  • PK: interactions Uricosuric/uricostatic
  • Assessing renal function
  • PK: renal failure
  • When is reduced renal clearance important?
  • PK: renal failure Narrow therapeutic range
  • PK: intermediate therapeutic index
  • PK: high therapeutic index
  • Increase in half-life
  • Pharmacodynamics What drugs do to the body?
  • PD: receptors
  • PD: interactions
  • Adverse drug reactions - definition Edwards and Aronson (Lancet 2000; 356:1255-1259)
  • Adverse drug reactions - epidemiology
  • Adverse drug reactions
  • Wayne Jowett
  • ADRs - old classification by dose Rawlins & Thompson (textbook of Adverse Drug Reactions, 1977)
  • ADRs - new classification
  • digoxin
  • ADRs - dose dependence
  • ADRs - dose dependence - phenytoin
  • ADRs - time-dependent
  • ADRs with an immunological basis and timing
  • ADRs - time-independent
  • ADRs - susceptibility
  • ADRs - sex susceptibility
  • ADRs - age susceptibility
  • Declines with age
  • Declines with age
  • ADRs - genetic susceptibility
  • Pharmacogenetics: acetylation 'PD HIPS'
  • Drug-induced lupus 'PCP HIPS'
  • ADRs - genetic susceptibility - P450 polymorphisms
  • ADRs - exogenous factors susceptibility
  • Liver Disease
  • Drugs causing liver disease hepatitis/necrosis
  • Drugs causing liver disease cholestasis
  • Steatosis - fatty liver
  • England-France
  • Hepatic encephalopathy
  • Renal Damage
  • ADRs: haemolysis
  • ADRs: G6PD + metHb
  • ADRs: methaemoglobin
  • ADRs: oxidizing agents
  • ADRs: unsafe in porphyria Enzyme inducers, centrally acting drugs +
  • Specific situations
  • Specific situations Pregnancy: teratogenic risks
  • Folate antagonists Neural-tube defects, cardiovascular defects, oral clefts, urinary tract defects
  • Specific situations Pregnancy: pharmacological risks
  • Some other drugs generally to be avoided in pregnancy
  • Relatively safe drugs in pregnancy
  • Specific situations Breast milk - unsafe
  • ADRs - pharmacovigilance spontaneous reporting
  • ADRs - pharmacovigilance (continued)
  • 5-amino salicylates
  • 5-ASA prodrugs - reduced + act in the colon
  • 5-ASA's - side effects
  • Video Feedback

Lecturer: Dr. Andrew Webb

MBBS London, BSc Physiology, MRCP (UK). After Andrew graduating from the University of London, Andrew trained as an Spr in General Medicine and Clinical Pharmacology at Barts and the London Hospital as well as Queen?s Mary?s Hospital, London. He is now a Consultant Physician in Clinical Pharmacology and General Medicine at Bart?s and the London NHS Trust, where he sits at the Research Advisory board. He has been teaching Clinical Pharmacology for 123Doc since 2001 and for Pastest since 2004.


  • 148 minutes


  • Fully animated, internet-enhanced presentation as used in the classroom lecture.
  • Adjustable streaming speed video for every user with broadband or dial-up internet access.
  • Ability to watch the video in installments and come back to the same point at any time in the future.
  • Complete script for users unable to listen to the presentation.
  • The 123Doc Clinical Pharmacology online video lecture is highly flexible, allowing you to study anytime, from any computer connected to the internet.

Suitable For

This eLecture is suitable for those studying for:

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Clinical Pharmacology6.002 months
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