Clinical Case Database / Category: Patient Management
Paraneoplastic retinopathy: a rare cause of visual loss
Publication details
Dr. David Miller, Dr. Graeme Williams, Dr. Donald M. Montgomery, Dr. Martin Galea
Foundation Years Journal, volume 9, issue 6, p.24 (123Doc Education, London, June 2015)
Abstract
Paraneoplastic syndromes are complexes of signs and symptoms in cancer patients. These result from dysfunction of tissues remote from the site of a malignant neoplasm or its metastases. Most of these syndromes occur as a result of ectopic tumour production of a hormone or functional growth factor acting at a distal site; whereas others are believed to involve immune-mediated cross-reactivity between tumour antigens and normal host tissues. Ocular paraneoplastic syndromes can be divided into 2 groups i.e. retinal and optic nerve based. The purpose of this article is twofold; firstly, we describe a case of probable Paraneoplastic Vitelliform maculopathy and discuss this condition in more detail. Secondly, it will remind the clinician of this relatively rare entity. Ocular paraneoplastic phenomena manifest subtle signs and are therefore easily overlooked and misdiagnosed.
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Authors
Dr. David Miller
Tennent Institute of Ophthalmology
Gartnavel General Hospital
1053, Great Western Road
Glasgow, G12 0YN
david.miller7@nhs.net
Dr. Graeme Williams
Tennent Institute of Ophthalmology
Gartnavel General Hospital
1053, Great Western Road
Glasgow, G12 0YN
graeme.williams@nhs.net
Dr. Donald M. Montgomery
Tennent Institute of Ophthalmology
Gartnavel General Hospital
1053, Great Western Road, Glasgow, G12 0YN
Glasgow Royal Infirmary
16 Alexandra Parade, Glasgow G31 2ER
Donald.Montgomery@ggc.scot.nhs.uk
Dr. Martin Galea (Corresponding author)
Tennent Institute of Ophthalmology
Gartnavel General Hospital
1053, Great Western Road
Glasgow, G12 0YN
martin.galea@doctors.org.uk
References
1. Rahimy E. Sarraf D. Paraneoplastic and non-paraneoplastic retinopathy and optic neuropathy: evaluation and management. Surv Ophthalmol. 2013 Sep-Oct;58(5): 430-58.
Disclaimers
Conflict Of Interest
The Journal requires that authors disclose any potential conflict of interest that they may have. This is clearly stated in the Journal’s published “Guidelines for Authors”. The Journal follows the Guidelines against Conflict of Interest published in the Uniform Requirements for Manuscripts Submitted to Biomedical Journals (http://www.icmje.org/urm_full.pdf).
Financial Statement
The authors of this article have not been paid. The Journal is financed by subscriptions and advertising. The Journal does not receive money from any other sources. The decision to accept or refuse this article for publication was free from financial considerations and was solely the responsibility of the Editorial Panel and Editor-in-Chief.
Patient Consent statement
All pictures and investigations shown in this article are shown with the patients’ consent. We require Authors to maintain patients’ anonymity and to obtain consent to report investigations and pictures involving human subjects when anonymity may be compromised. The Journal follows the Guidelines of the Uniform Requirements for Manuscripts (http://www.icmje.org/urm_full.pdf). The Journal requires in its Guidelines for Authors a statement from Authors that “the subject gave informed consent”.
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When reporting experiments on human subjects, the Journal requires authors to indicate whether the procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the HelsinkiDeclaration of 1975, as revised in 2008.
About the Clinical Cases Database
The Foundation Years Clinical Cases Database is a selection of 600 peer-reviewed clinical cases in the field of patient safety and clinical practice, specifically focused on the clinical information needs of junior doctors, based around the Foundation Year Curriculum programme (MMC). The cases have been chosen to align with the Foundation Year Curriculum.
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