Clinical Case Database / Category: Case Based Discussion
Motor neuron disease
Publication details
Thomas W Payne, Christopher J McDermott
Foundation Years Journal, volume 7, issue 7, p.42 (123Doc Education, London, July 2013)
Abstract
Mr Smith is 72 year old retired teacher who has been electively admitted to the Care of the Elderly ward with a 6 month history of progressive lower limb weakness. He now states he has difficulty swallowing. Your consultant is concerned he may have Motor Neuron Disease and wants to investigate him further with respect to this. You are the F1 and have been asked to clerk him, what do you need to be aware of?
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Authors
Thomas W Payne
The Medical School, University of Sheffield,
Beech Hill Road,
Sheffield, S10 2RX
Christopher J McDermott
Sheffield Institute for Translational Neuroscience,
University of Sheffield,
385A Glossop Road,
Sheffield, S10 2HQ
References
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2. P. G. Ince, R. J. Highley, J. Kirby, S. B. Wharton, H. Takahashi, M. J. Strong and P. J. Shaw. Molecular pathology and genetic advances in amyotrophic lateral sclerosis: an emerging molecular pathway and the significance of glial pathology. Acta Neuropathol 2011, 122:657 671.
3. H. R. Morris, A. J. Waite, N. M. Williams, J. W. Neal and D. J. Blake. Recent Advances in the Genetics of the ALS-FTLD Complex. Curr Neurol Neurosci Rep 2012, 12:243-250.
4. A. Eisen and M. Swash. Clinical neurophysiology of ALS. Clinical Neurophysiology 2001, 112:2190-2201.
5. S. Wang, E. R. Melhem, H. Poptani and J. H. Woo. Neuroimaging in Amyotrophic Lateral Sclerosis. Neurotherapeutics 2011, 8(1):63-71.
6. R. G. Miller, J. D. Mitchell and D. H. Moore. Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND). Cochrane Database of Systematic Reviews 2012, 3.
7. S. C. Bourke, R. E. Bullock, T. L. Williams, P. J. Shaw and G. J. Gibson. Noninvasive ventilation in ALS: Indications and effect on quality of life. Neurology 2003, 61(2):171-177.
8. P. M. Andersen, S. Abrahams and G. D. Borasio, et al. EFNS guidelines on the Clinical Management of Amyotrophic Lateral Sclerosis (MALS) – revised report of an EFNS task force. Eur J Neurol 2012, 19:360-375.
9. C. J. McDermott, C. Maguire and C. L. Cooper, et al. Protocol for diaphragm pacing in patients with respiratory muscle weakness due to motor neurone disease (DiPALS): a randomised controlled trial. BMC Neurology 2012, 12:74.
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About the Clinical Cases Database
The Foundation Years Clinical Cases Database is a selection of 600 peer-reviewed clinical cases in the field of patient safety and clinical practice, specifically focused on the clinical information needs of junior doctors, based around the Foundation Year Curriculum programme (MMC). The cases have been chosen to align with the Foundation Year Curriculum.
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