Clinical Case Database / Category: Patient Management
Isolated proteinuria - how to screen, how to measure, how to interpret
Publication details
Muhammad Azhar Khan MBBS MRCP, Jamie Barfield MBChB, Michael Schulz MD FRCP
Foundation Years Journal, volume 5, issue 2, p.65 (123Doc Education, London, March 2011)
Abstract
Proteinuria is an important indicator of underlying kidney disease and its presence and quantity is an independent risk factor for both progression of CKD and cardiovascular disease. Routine urinalysis for screening purposes is recommended for high risk patients particularly those with diabetes or hypertension. Furthermore changes in proteinuria have been suggested as a surrogate outcome for kidney disease progression. This article will review the evaluation of a patient with isolated proteinuria and the way of screening and measuring for proteinuria will be explained here.
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Authors
Muhammad Azhar Khan MBBS MRCP
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Jamie Barfield MBChB
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Michael Schulz MD FRCP
Consultant Nephrologist
Royal Liverpool and Broadgreen University Hospital
Liverpool
References
1. Keane WF. Proteinuria: its clinical importance and role in progressive renal disease. Am J Kidney Dis 2000; 35: S97–S105
2. Ruggenenti P, Perna A, Mosconi L, Matalone M, Pisoni R, Gaspari F, Remuzzi G: Proteinuria predicts end-stage renal failure in non-diabetic chronic nephropathies. The “Gruppo Italiano di Studi Epidemiologici in Nefrologia†(GISEN). Kidney Int Suppl 1997; 63: S54–S57
3. National Institute for Health and Clinical Excellence. Chronic Kidney Disease. September 2008 Available from http://www.nice.org.uk/nicemedia/ pdf/CG073QuickRefGuide.pdf
4. Mir S, Kütükçüler N, Cura A. Use of single voided urine samples to estimate quantitative proteinuria in children.Turk J Pediatr.1992;34(4):219-24
5. Schwab SJ, Christensen RL, Dougherty K, Klahr S. Quantitation of proteinuria by the use of protein-to-creatinine ratios in single urine samples. Arch Intern Med. 1987;147(5):943-4
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About the Clinical Cases Database
The Foundation Years Clinical Cases Database is a selection of 600 peer-reviewed clinical cases in the field of patient safety and clinical practice, specifically focused on the clinical information needs of junior doctors, based around the Foundation Year Curriculum programme (MMC). The cases have been chosen to align with the Foundation Year Curriculum.
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