Clinical Case Database / Category: Patient Management
Investigation and management of chronic hepatitis C virus infection
Publication details
Elspeth Bird BSc MBBS, Shahid A Khan BSc MBBS PhD FRC P (Lond), Matthew L Cowan BSc MRC P
Foundation Years Journal, volume 5, issue 8, p.1 (123Doc Education, London, September 2011)
Abstract
Chronic infection with the hepatitis C virus (HCV) is a major and increasing health problem affecting approximately 185,000 people in the UK in 2009. Longstanding hepatic inflammation can lead to progressive fibrosis that may result in cirrhosis, decompensated liver disease and/or hepatocellular carcinoma. Effective antiviral treatment exists which can cure over 50% of patients. This case-based discussion will focus on the presentation, clinical findings, key investigations and management of a 56 year-old lady with newly diagnosed chronic HCV.
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Authors
Elspeth Bird BSc MBBS
Specialist Trainee 1 Imperial College London Liver Unit,
St Mary's Hospital Campus
Shahid A Khan BSc MBBS PhD FRC P (Lond)
Consultant Hepatologist and Clinical Senior Lecturer
Imperial College London Liver Unit, St Mary's Hospital Campus
Matthew L Cowan BSc MRC P
Consultant Hepatologist Imperial College London Liver Unit, St Mary's Hospital Campus
matthew.cowan@imperial.nhs.uk
References
1. Ghany MG, Strader DB, Thomas DL, Seeff LB. Diagnosis, management, and treatment of hepatitis C: an update. Hepatology. 2009 Apr;49(4):1335-74.
2. Uddin G, Shoeb D, Solaiman S, Marley R, Gore C, Ramsay M, et al. Prevalence of chronic viral hepatitis in people of south Asian ethnicity living in England: the prevalence cannot necessarily be predicted from the prevalence in the country of origin. J Viral Hepat. 2010 May
1;17(5):327-35.
3. Castera L, Forns X, Alberti A. Non-invasive evaluation of liver fibrosis using transient elastography. Journal of hepatology. 2008 May;48(5):835-47.
4. NICE. NICE technology appraisal guidance 106 Peginterferon alfa and ribavirin for the treatment of mild chronic hepatitis C. National Institute for Health and Clinical Excellence; 2006.
5. McHutchison JG, Manns MP, Muir AJ, Terrault NA, Jacobson IM, Afdhal NH, et al. Telaprevir for previously treated chronic HCV infection. N Engl J Med. 2010 Apr 8;362(14):1292-303.
6. Hezode C, Forestier N, Dusheiko G, Ferenci P, Pol S, Goeser T, et al. Telaprevir and peginterferon with or without ribavirin for chronic HCV infection. N Engl J Med. 2009 Apr 30;360(18):1839-50.
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About the Clinical Cases Database
The Foundation Years Clinical Cases Database is a selection of 600 peer-reviewed clinical cases in the field of patient safety and clinical practice, specifically focused on the clinical information needs of junior doctors, based around the Foundation Year Curriculum programme (MMC). The cases have been chosen to align with the Foundation Year Curriculum.
The database is fully searchable, or can be browsed by medical specialty. Abstracts can be read free of charge, however a subscription is required in order to read the complete cases.