Clinical Case Database / Category: Patient Management

Investigation & management of idiopathic intracranial hypertension

Publication details

Dr Syed Amir Zaidi MBBS, MRCP, Tahir Majeed MBBS, FRCP, PHD
Foundation Years Journal, volume 7, issue 7, p.32 (123Doc Education, London, July 2013)


This case focuses the presentation, investigations and management of patient with Idiopathic intracranial hypertension. We emphasise the importance of early recognition, diagnosis and treatment of Idiopathic intracranial hypertension to prevent serious complications like visual loss.

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Dr Syed Amir Zaidi MBBS, MRCP (Corresponding author)

Clinical Fellow Neurology
Royal Preston Hospital

Tahir Majeed MBBS, FRCP, PHD

Consultant Neurologist at Royal Preston Hospital


1. Friedman DI, Jacobson DM.Diagnostic criteria for Idiopathic intracranial hypertension. Neurology 2002; 59:1492-5
2. Durcan FJ, Corbett JJ, Wall M. The incidence of pseudotumour cerebri population studies in Iowa and Louisiana. Arch Neurol 1988; 45:875–7.
3. Wall M. The headache profile of idiopathic intracranial hypertension. Cephalalgia 2002; 10:331–5.
4. Wall M, George D. Idiopathic intracranial hypertension (pseudotumour cerebri), a prospective study of 50 patients. Brain 1991; 114:155–80.
5. Sismanis A, Butts FM, Hughes GB: Objective tinnitus in benign intracranial hypertension: An update. Laryngoscope 1990; 100:33–36.
6. Sismanis A, Hughes GB, Abedi E, Williams GH, Isrow LA: Otologic symptoms and findings of the pseudotumor cerebri syndrome: A preliminary report. Otolaryngol Head Neck Surg 1985;93:398–402.
7. Wall M, George D. Idiopathic intracranial hypertension (pseudotumour cerebri), a prospective study of 50 patients. Brain 1991; 114:155–80.
8. Krishna R, Kosmorsky GS, Wright KW: Pseudotumor cerebri sine papilloedema with unilateral sixth nerve palsy. J Neuroophthalmol 1998; 18:53–55.
9. Tomsak RL, Niffenegger AS, Remler BF. Treatment of pseudotumor cerebri with Diamox (acetazolamide) J Clin Neuro-ophthalmol.1988; 8:93–98.
10. Padeh S, Passwell JH. Systemic lupus erythematosus presenting as idiopathic intracranial hypertension.J Rheumatol 1996; 23:1266–8.
11. Guy J, Johnston PK, Corbett JJ, Day AL, Glaser JS. Treatment of visual loss in pseudotumor cerebri associated with uraemia. Neurology 1990; 40:28–32.
12. Celebisoy N, Gokcay F, Sirin H, Akyurekli O. Treatment of idiopathic intracranial hypertension: topiramate vs acetazolamide, an open-label study. Acta Neurol Scand. 2007; 116:322–327.
13. Campos SP, Olitsky S. Idiopathic intracranial hypertension after l-thyroxine therapy for acquired primary hypothyroidism. Clin Pediatr 1995; 34:334–7.
14. Kupersmith MJ, Gamell L, Turbin R, Peck V, Spiegel P, Wall M. Effects of weight loss on the course of idiopathic intracranial hypertension in women. Neurology 1998; 50:1094–8.
15. Johnson LN, Krohel GB, Madsen RW, March GA Jr. The role of weight loss and acetazolamide in the treatment of idiopathic intracranial hypertension (pseudotumor cerebri). Ophthalmology 1998; 105: 2313–7.
16. Kelman SE, Heaps R, Wolf A. Optic nerve decompression surgery improves visual function in patients with pseudotumor cerebri. Neurosurgery 1992; 30:391–5.
17. Eggenberger ER, Miller NR, Vitale S. Lumboperitoneal shunt for the treatment of pseudotumor cerebri. Neurology 1996; 46:1524–30.
18. Plotnik JL, Kosmorsky GS. Operative complications of optic nerve sheath decompression. Ophthalmology 1993; 100:683–90.
19. Giuseffi V, Wall M, Siegel PZ, Rojas PB.Symptomas ad disease association in Idiopathic intracranial hypertension (pseudotumor cerebri): A case control study. Neurology 1991; 41:239-44
20. Gardner K, Cox T, Digre KB. Idiopathic intracranial hypertension associated with tetracycline use in fraternal twins: case reports and review. Neurology 1995; 45:6–1
21. Spector RH, Carlisle J. Pseudotumor cerebri caused by a synthetic vitamin A preparation. Neurology 1984; 34: 1509–11.
22. Levine SH, Puchalski C: Pseudotumor cerebri associated with lithium therapy in two patients. J Clin Psychiatry 1990;51:251–253.
23. Palacio E, Rodero L, Pascaul J.Tpiramate responsive headaches due to Idiopathic intracranial hypertension in Behcet syndrome. Headache 2004; 44:436-7.
24. Whiteley W, Al Shahi R, Warlow CP, Zeidler M, Lueck CJ. CSF opening pressure: reference interval and the effect of body mass index. Neurology. 2006;67:1690–1691.
25. Whiteley W, Al Shahi R, Zeidler M, Warlow CP Brief Communications: CSF opening pressure: Reference interval and the effect of body mass index. Neurology. 2007.
26. Corbett JJ, Mehta MP. Cerebrospinal fluid pressure in normal obese subjects and patients with pseudotumor cerebri. Neurology. 1983;33:1386–1388.


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T​he Foundation Years Clinical Cases Database is​ a selection of 600 peer-reviewed clinical cases in the field of patient safety and clinical practice, specifically focused on the clinical information needs of junior doctors, based around the Foundation Year Curriculum programme (MMC). The cases have been chosen to align with the Foundation Year Curriculum.

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