Clinical Case Database / Category: Clinical Care
Infections & necrotising enterocolitis in newborn Infants
Publication details
Dr Thomas Skeath, Dr Nicholas Embleton
Foundation Years Journal, volume 8, issue 8, p.26 (123Doc Education, London, September 2014)
Abstract
Sepsis and necrotising enterocolitis are the most prevalent, yet potentially preventable causes of serious perinatal morbidity and mortality within the neonatal period. 1 in 10 deaths in infants born <32 weeks gestation is due to infection (1). There is a wide range of conditions leading to illness in the neonatal period, but gestation and age at presentation are important factors in terms of the key morbidities, and infections are normally described using these categories. Premature or preterm delivery (<37 completed weeks gestation) is associated with different risk factors to those born at term. Early Onset Sepsis (EOS) occurs in the first 2-3 days of life, whereas Late Onset Sepsis (LOS) occurs thereafter and is usually caused by organisms acquired after delivery.
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Authors
Dr Thomas Skeath (Corresponding author)
Clinical Research Fellow RVI Newcastle
Neonatal Department
Royal Victoria Hospital
Queen Victoria Road
Newcastle Upon Tyne
NE1 4LP
thomas.skeath@nuth.nhs.uk
Dr Nicholas Embleton
Consultant Neonatologist
Neonatal Department
Royal Victoria Hospital
Queen Victoria Road
Newcastle Upon Tyne
NE1 4LP
nicholas.embleton@newcastle.ac.uk
References
2. Stoll B.J., Hansen N.I., Adams-Chapman I., Fanaroff A.A., Hintz S.R., Vohr B., Higgins R.D. et National Institute of Child Health and Human Development Neonatal Research Network. (2004). Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection. JAMA, 292(19), 2357–2365.
3. National Institute for Health and Clinical Excellence. Antibiotics for early-onset neonatal infection: antibiotics for the prevention and treatment of early-onset neonatal infection. London: NICE; 2012. Available from: http://www.nice.org.uk/nicemedia/live/13867/60633/60633.pdf
7. Kempley S, Gupta N, Linsell L, Dorling J, McCormick K, Mannix P, Juszczak E, Brocklehurst P, Leaf A; ADEPT Trial Collaborative Group. Feeding infants below 29 weeks’ gestation with abnormal antenatal Doppler: analysis from a randomised trial. Arch Dis Child Fetal Neonatal Ed. 2014 Jan;99(1):F6-F11. doi: 10.1136/archdischild-2013-304393. Epub 2013 Aug 23.
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