Clinical Case Database / Category: Clinical Care

Immunosuppression in renal transplantation

Publication details

Muhammad Jameel, Laszlo Szabo, Rafael Chavez
Foundation Years Journal, volume 6, issue 7, p.6 (123Doc Education, London, July 2012)

Abstract

Kidney transplant is the best available treatment for end-stage renal disease. It leads to improved quality of life, prolonged survival and is cost effective compared to dialysis. Despite the above advantages it is related to significant morbidity and mortality due to opportunistic infection and other complications as a consequence of immunosuppression. Here we discuss three renal transplant cases that illustrate some of these complications.

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Authors

Muhammad Jameel

Specialist Registrar in Transplant Surgery
Cardiff Transplant Unit
University Hospital Wales
Heath Park, Cardiff
CF14 4XW

Laszlo Szabo

Clinical Fellow in Transplantation
Cardiff Transplant Unit
University Hospital Wales
Heath Park, Cardiff
CF14 4XW

Rafael Chavez (Corresponding author)

Consultant General & Transplant Surgeon
Cardiff Transplant Unit
University Hospital Wales
Heath Park, Cardiff
CF14 4XW

Phone: 02920 746647
Fax: 02920 746661
Rafael.Chavez@wales.nhs.uk

References

1. Black H. Generic versus branded medication in transplantation. British Journal of Renal Medicine. 2011; 16(3):4-6
2. Murray JE, Merrill JP, Dammin GJ, et al. Study of transplantation immunity after total body irradiation: clinical and experimental investigation. Surgery. 1960; 48:272-284.
3. Calne RY, Alexandre GP, Murray JE. A study of the effects of drugs in prolonged survival of homologous renal transplantation in dogs. Ann N Y Acad Sci. 1962;99:743-761.
4. Starzl TE, Marchioro TL, Waddell WR. The reversal of rejection in human renal homografts with subsequent development of homograft tolerance. Surg Gynecol Obstet. 1963;117:385-395.
5. Veroux M, Giuffrida G, Corona D, et al. Infective complications in renal allograft recipients: epidemiology and outcome. Transplant Proc. 2008;40:1873-1876.
6. Charfeddine K, Zaghden S, Kharrat M, et al. Infectious complications in kidney transplant recipients: a single-center experience. Transplant Proc. 2005;37:2823-2825.
7. Fishman J, Rubin R. Infection in organ-transplant recipients. N Engl J Med. 1998;338:1741-1750.

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T​he Foundation Years Clinical Cases Database is​ a selection of 600 peer-reviewed clinical cases in the field of patient safety and clinical practice, specifically focused on the clinical information needs of junior doctors, based around the Foundation Year Curriculum programme (MMC). The cases have been chosen to align with the Foundation Year Curriculum.

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