Clinical Case Database / Category: Case Based Discussion
Fertility after chemotherapy
Publication details
Sacco JJ, O’Reilly SM
Foundation Years Journal, volume 6, issue 9, p.38 (123Doc Education, London, October 2012)
Abstract
A significant proportion of patients who undergo chemotherapy for cancer become infertile as a result. Following substantial improvements in the management of several solid tumour types, increasing numbers of patients are surviving cancer and chemotherapy. The average age at which people start their families is also increasing, and both factors have led to greater numbers of patients facing chemotherapy related infertility, and the associated social and psychological stress. Here we present two illustrative cases, one involving a woman undergoing adjuvant chemotherapy for breast cancer, and the second a man undergoing chemotherapy for testicular cancer. We will discuss the salient points raised by each case, and in particular, the options currently available for fertility preservation.
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Authors
Sacco JJ
Clatterbridge Cancer Centre
Clatterbridge Road
Bebington
Wirral
CH63 4JY
O’Reilly SM
Clatterbridge Cancer Centre
Clatterbridge Road
Bebington
Wirral
CH63 4JY
sue.oreilly@clatterbridgecc.nhs.uk
References
1. Letourneau JM, Smith JF, Ebbel EE, et al. Racial, socioeconomic, and demographic disparities in access to fertility preservation in young women diagnosed with cancer. Cancer 2012, doi: 10.1002/cncr.26649. [Epub ahead of print]
2. Schover LR, Rybicki LA, Martin BA, et al. Having children after cancer. A pilot survey of survivors’ attitudes and experiences, Cancer 1999, 86: 697-709.
3. Lee SJ, Schover LR, Partridge AH, et al. American Society of Clinical Oncology recommendations on fertility preservation in cancer patients. J Clin Oncol 2006, 24: 2917-2931.
4. Oktay K, Cil AP, Bang H. Efficiency of oocyte cryopreservation: a metaanalysis. Fertil Steril 2006, 86:70-80
5. Porcu E, Bazzocchi A, Notarangelo L et al. Human oocyte cryopreservation in infertility and oncology. Curr Opin Endocrinol Diabetes Obes 2008, 15: 529-535.
6. Donnez J, Dolmans MM. Cryopreservation of ovarian tissue: an overview. Minerva Med 2009, 100:401-413.
7. Bedaiwy MA, Abou-Setta AM, Desai N, et al. Gonadotropin-releasing hormone analog cotreatment for preservation of ovarian function during gonadotoxic chemotherapy: a systematic review and meta-analysis., Fertil Steril 2011, 95:906-914
8. Oktay K. Further evidence on the safety and success of ovarian stimulation with letrozole and tamoxifen in breast cancer patients undergoing in vitro fertilization to cryopreserve their embryos for fertility preservation. J Clin Oncol 2005, 23:3858-3859.
9. Dodds L, Marrett LD, Tomkins DJ, et al. Case-control study of congenital anomalies in children of cancer patients. BMJ 1993, 307:164-168.
10. Meistrich ML, Byrne J. Genetic disease in offspring of long-term survivors of childhood and adolescent cancer treated with potentially mutagenic therapies. Am J Hum Genet 2002, 70:1069-1071.
11. Braems G, Denys H, De Wever O et al. Use of tamoxifen before and during pregnancy., Oncologist 2011, 16:1547-1551.
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The Foundation Years Clinical Cases Database is a selection of 600 peer-reviewed clinical cases in the field of patient safety and clinical practice, specifically focused on the clinical information needs of junior doctors, based around the Foundation Year Curriculum programme (MMC). The cases have been chosen to align with the Foundation Year Curriculum.
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