Clinical Case Database / Category: Patient Management

Eosinophilic oesophagitis (EoE)

Publication details

Dr Rhys Hewett MBBS, MSc, MRCP, Dr Jamal Hayat BSc, MBBS, MRCP, Prof Jin-Yong Kang MD, PhD, FRCP, Dr Andrew Poullis BSc, MD, FRCP
Foundation Years Journal, volume 9, issue 2, p.34 (123Doc Education, London, February 2015)


Eosinophilic oesophagitis (EoE) was first described in adult patients in the early 1980's and has since become an increasingly recognised cause of oesophageal dysfunction. It is characterised by symptoms, such as dysphagia and food bolus obstruction, in conjunction with characteristic endoscopic and histological appearances. Treatment usually consists of topical oesophageal steroids, but other therapies are also used. This case-based discussion will include clinical presentation, investigational findings, pathophysiology and management.

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Dr Rhys Hewett MBBS, MSc, MRCP (Corresponding author)

Clinical Research Fellow, Department of Gastroenterology,
St George's Hospital, Blackshaw Road, Tooting, London, SW17 0QT

Dr Jamal Hayat BSc, MBBS, MRCP

Consultant Gastroenterologist, Department of Gastroenterology,
St George's Hospital, Blackshaw Road, Tooting, London, SW17 0QT

Prof Jin-Yong Kang MD, PhD, FRCP

Consultant Gastroenterologist, Department of Gastroenterology,
St George's Hospital, Blackshaw Road, Tooting, London, SW17 0QT

Dr Andrew Poullis BSc, MD, FRCP

Consultant Gastroenterologist, Department of Gastroenterology,
St George's Hospital, Blackshaw Road, Tooting, London, SW17 0QT


1. Desai TK, Stecevic V, Chang CH, et al. Association of eosinophilic inflammation with esophageal food impaction in adults. Gastrointest Endosc 2005, 61:795–801.
2. Trenkner SW, Maglinte DD, Lehman GA, et al. Esophageal food impaction: treatment with glucagon. Radiology 1983, 149(2):401-3.
3. Noel RJ, Putnam PE, Collins MH, et al. Clinical and immunopathologic effects of swallowed fluticasone for eosinophilic esophagitis. Clin Gastroenterol Hepatol 2004, 2(7):568-75.
4. Straumann A., Conus S., Degen L, et al. Budesonide is effective in adolescent and adult patients with active eosinophilic esophagitis. Gastroenterology 2010, 139(5):1526–1537.
5. Gonsalves N, Yang GY, Doerfler B, et al. Elimination diet effectively treats eosinophilic esophagitis in adults; food reintroduction identifies causative factors. Gastroenterology 2012, 142(7):1451-9.
6. Cheng E, Zhang X, Huo X, et al. Omeprazole blocks eotaxin-3 expression by oesophageal squamous cells from patients with eosinophilic oesophagitis and GORD. Gut 2013, 62(6):824-32.
7. Dellon ES, Speck O, Woodward K, et al. Clinical and endoscopic characteristics do not reliably differentiate PPI-responsive esophageal eosinophilia and eosinophilic esophagitis in patients undergoing upper endoscopy. Am J Gastroenterol 2013, 108(12):1854-1860.
8. Read AJ, Pandolfino JE. Biomechanics of esophageal function in eosinophilic esophagitis. J Neurogastroenterol Motil 2012, 18(4):357-64.
9. Rothenberg ME. Biology and treatment of eosinophilic esophagitis. Gastroenterology 2009, 137:1238–1249.
10. Kagalwalla AF, Akhtar N, Woodruff SA, et al. Eosinophilic esophagitis: epithelial mesenchymal transition contributes to esophageal remodelling and reverses with treatment. J Allergy Clin Immunol 2012, 129(5):1387-1396.
11. Kwiatek MA, Hirano I, Kahrilas PJ, et al. Mechanical properties of the esophagus in eosinophilic esophagitis. Gastroenterology 2011, 140(1):82-90.
12. Korsapati H, Babaei A, Bhargava V, et al. Dysfunction of the longitudinal muscles of the oesophagus in eosinophilic oesophagitis. Gut 2009, 58(8):1056-62


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T​he Foundation Years Clinical Cases Database is​ a selection of 600 peer-reviewed clinical cases in the field of patient safety and clinical practice, specifically focused on the clinical information needs of junior doctors, based around the Foundation Year Curriculum programme (MMC). The cases have been chosen to align with the Foundation Year Curriculum.

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