Clinical Case Database / Category: Patient Management
Endometriosis
Publication details
Dr Sarah Solangon MBBS, BSc (Hons), Mr George Goumalatsos, MRCOG, Professor Janice Rymer MD, FRCOG, FRANZCOG, FHEA
Foundation Years Journal, volume 8, issue 9, p.24 (123Doc Education, London, October 2014)
Abstract
Dysmenorrhoea and dyspareunia are common symptoms in gynaecology, endometriosis being high on your differential list. Often diagnosed months to years after the onset of symptoms, endometriosis can be difficult to manage, particularly when involving organs such as bowel or urinary tract and distressing as a cause of infertility. Despite various staging systems, the extent of the disease does not correlate well with pain. In this article we discuss the different management options based on the most updated evidence and reviews. Management of endometriosis must be patient-centred and often involves long-term follow up and trials of various treatments. Reassurance and good communication skills are of utmost importance.
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Authors
Dr Sarah Solangon MBBS, BSc (Hons)
Foundation Year 2 Doctor
Guy's and St Thomas' Hospital
Westminster Bridge Road, London, SE1 7EH
anniesolangon@doctors.org.uk
Mr George Goumalatsos, MRCOG
Senior Registrar in Obstetrics and Gynaecology
Tunbridge Wells Hospital, Tonbridge Road
Pembury, Kent, TN2 4QJ
goumalatsos@me.com
Professor Janice Rymer MD, FRCOG, FRANZCOG, FHEA
Dean of Student Affairs and Lead for Twinned Institutions
Professor of Gynaecology, King's College School of Medicine, London
janice.rymer@kcl.ac.uk
References
1. Eskenazi B & Warner ML. Epidemiology of endometriosis. Obstet Gynecol Clin North 1997, 24:235-258.
2. Ozkan S, Murk W, Arici A. Endometriosis and Infertility. Epidemiology and evidence based treatments. Annals of the New York Academy of Sciences 2008, 1127:92-100.
3. Sinaii N, Plumb K, Cotton L, et al. Differences in characteristics among 1,000 women with endometriosis based on extent of disease. Fertil Steril, 2008, 89:538-545.
4. McLaren J, Prentice A. New aspects of pathogenesis of endometriosis. Current Obstetrics and Gynaecology 1996, 6:85-91.
5. Giudice LC, Kao LC. Endometriosis. Lancet 2004, 364:1789-99.
6. Rahmioglu N et al. Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets. Hum Reprod Update, 2014, March 27.
7. Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertil Steril. 1997, 67(5):817-92.
8. Vercellini P, Fedele L, Aimi G et al. Association between endometriosis stage, lesion type, patient characteristics and severity of pelvic pain symptoms: a multivariate analysis of over 1000 patients. Hum Reprod 2007, 22:266â€"271.
9. Haas D et al. Efficacy of the revised Enzian classification: a retrospective analysis. Does the revised Enzian classification solve the problem of duplicate classification in rASRM and Enzian?Arch Gynecol Obstet. 2013, 287(5):941-5.
10. Adamson GD. Endometriosis Fertility Index: is it better than the present staging systems? Curr Opin Obstet Gynecol. 2013, 25(3):186-92.
11. Tomassetti C et al. External validation of the endometriosis fertility index (EFI) staging system for predicting non-ART pregnancy after endometriosis surgery. 2013, 28(5):1280-8.
12. Practice Committee ASRM, 2012
13. Giudice L, Evers JLH, Healy DL. Endometriosis: science and practice. Oxford: Wiley-Blackwell, 2012.
14. Chen FP et al. The use of serum CA-125 as a marker for endometriosis in patients with dysmenorrhea for monitoring therapy and for recurrence of endometriosis. Acta Obstet Gynecol Scand. 1998, 77(6):665-70.
15. Agic A et al. Combination of CCR1 mRNA, MCP1, and CA125 measurements in peripheral blood as a diagnostic test for endometriosis. Reprod Sci. 2008, 15(9):906-11
16. Moore J et al. A systematic review of the accuracy of ultrasound in the diagnosis of endometriosis. Ultrasound Obstet Gynecol. 2002, 20:630â€"634.
17. Patel MD et al. Endometriomas: diagnostic performance of US. Radiology, 1999, 210:739â€"745.
18. Takeuchi H et al. A novel technique using magnetic resonance imaging jelly for evaluation of rectovaginal endometriosis. Fertil Steril, 2005, 83(2):442-7.
19. Bazot M et al. Diagnostic accuracy of physical examination, transvaginal sonography, rectal endoscopic sonography, and magnetic resonance imaging to diagnose deep infiltrating endometriosis. Fertil Steril, 2009, 92:1825â€"33.
20. Kobayashi H. Ovarian cancer in endometriosis: epidemiology, natural history, and clinical diagnosis. Int. J. Clin. Oncol. 2009, 14(5):378-8.
21. Allen C et al. Nonsteroidal anti-inflammatory drugs for pain in women with endometriosis. Cochrane Database Syst Rev. 2009;CD004753.
22. Nawathe A et al. Systematic review of the effects of aromatase inhibitors on pain associated with endometriosis. BJOG. 2008, 115(7):818-22.
23. Moore J, Kennedy SH, Prentice A. Modern combined oral contraceptives for pain associated with endometriosis. Cochrane Database Syst Rev. 2000, (2):CD001019.
24. Abou-Setta AM et al. Levonorgestrel-releasing intrauterine device for symptomatic endometriosis following surgery. Cochrane database of Systematic Reviews 2013, Issue 1.
25. Brown J, Pan A, Hart RJ. Gonadotrophin-releasing hormone analogues for pain associated with endometriosis. Cochrane Database of Systematic Reviews 2012, Issue 12.
26. McLaren JS1, Morris E, Rymer J. Gonadotrophin receptor hormone analogues in combination with add-back therapy: an update. Menopause Int, 2012, 18(2):68-72.
27. Surrey, ES & Hornstein MD. Prolonged GnRH Agonist and Add-Back Therapy for Symptomatic Endometriosis: Long term Follow-up. Obstet Gynaecol, 2002, (99):709-719.
28. Sallam HN et al. Long-term pituitary down-regulation before in vitro fertilization (IVF) for women wit h endometriosis. Cochrane Database Syst Rev, 2006, (1):CD004635.
29. Farquhar C et al. Danazol for pelvic pain associated with endometriosis. Cochrane Database of Systematic Reviews, 2007, Issue 4.
30. Brown J, Farquhar C. Endometriosis: an overview of Cochrane Reviews. Cochrane Database of Systematic Reviews 2014, Issue 3.
31. Cheong YC, Smotra G, Williams ACDC. Non-surgical interventions for the management of chronic pelvic pain. Cochrane Database of Systematic Reviews 2014, Issue 3.
32. Wilson ML, Murphy PA. Herbal and dietary therapies for primary and secondary dysmenorrhoea. Cochrane Database Syst Rev, 2001, (3):CD002124.
33. Duffy JMN et al. Laparoscopic surgery for endometriosis. Cochrane Database of Systematic Reviews, 2014, Issue 4.
34. Sirota I1, Nezhat F. Long-term outcomes in robotic compared with conventional laparoscopy for the treatment of severe endometriosis. Obstet Gynecol, 2014,123 Suppl 1:128-9.
35. Jones KD, Sutton C. Patient satisfaction and changes in pain scores after ablative laparoscopic surgery for stage III-IV endometriosis and endometriotic cysts. Fertil Steril, 2003, 79(5):1086-90.
36. Beretta P et al. Randomized clinical trial of two laparoscopic treatments of endometriomas: cystectomy versus drainage and coagulation. Fertility and Sterility, 1998, 70:1176â€"80.
37. Alborzi S et al. A prospective, randomized study comparing laparoscopic ovarian cystectomy versus fenestration and coagulation in patients with endometriomas. Fertil Steri, 2004, 82(6):1633-7.
38. Hart RJ et al. Excisional surgery versus ablative surgery for ovarian endometriomata. Cochrane Database Syst Rev, 2008, vol. 16, no.2.
39. Proctor ML et al. Surgical interruption of pelvic nerve pathways for primary and secondary dysmenorrhoea. Cochrane Database Syst Rev, 2005;CD001896.
40. Abbott J et al. Laparoscopic excision of endometriosis: a randomised, placebo-controlled trial. Fertility and Sterility, 2004,82:878-84.
41. Vercellini P et al. The effect of surgery for symptomatic endometriosis: the other side of the story. Hum Reprod Update, 2009, 15(2):177-8
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