Clinical Case Database / Category: Patient Management

Diffuse large B-cell lymphoma occurring in a patient with hairy cell leukemia and prostatic adenocarcinoma

Publication details

G Anghel, MD, Gabriel Anghel, MD
Foundation Years Journal, volume 5, issue 7, p.35 (123Doc Education, London, August 2011)


A 75 year-old man with previous history (of prostatic adenocarcinoma) was referred for evaluation of pancytopenia in December 2006. A diagnosis of hairy cell leukaemia (HCL) was made. The patient was commenced 2 cloro-deoxyadenosine treatment, attaining a complete remission. Four months later he presented with inguinal & supraclavicular lymphadenopathy, and hypercalcemia. A lymph node biopsy revealed infiltration by diffuse large B cell lymphoma (DLBCL). Though HCL is associated with increase incidence of second malignancies, simultaneous occurrence of DLBCL and HCL remains an uncommon event. A literature review showed only 13 cases have been published to date. The origin and clonal relationship of heavy or light chains immunoglobulin genes in the two pathologies is also discussed.

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G Anghel, MD

Consultant Haematologist

Gabriel Anghel, MD

Consultant Haematologist,
Haematology Dept. - LCH,
United Lincolnshire Hospitals NHS Foundation Trust,
Greetweel Road, Lincoln. LN2 5QY


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