Clinical Case Database / Category: Case Based Discussion
Diagnosis and management of hypercalcaemia
Publication details
SP Harger, HD Brooks, PJ Twomey
Foundation Years Journal, volume 2, issue 10, p.412 (123Doc Education, London, December 2008)
Abstract
A 55-year-old teacher presents to the medical admissions unit with a 3-week history of polydipsia, polyuria and constipation. Further history reveals she had been fatigued, with poor concentration and myalgia for at least 6 weeks. She was previously well having never smoked, and drinking between 4-7 units of alcohol per week. She had her last menstrual period at the age of 51 and is on bendrofl umethiazide 2.5 mg once daily for mild hypertension. Examination is unremarkable, though she mentions a generalised aching pain in her proximal muscles, which are mildly weak (4/5 power).
Access the Clinical Cases Database
A subscription is required to read the full article. Please subscribe using one of the options below.
Product | Price | Subscription | |
---|---|---|---|
Foundation Years Clinical Cases Database | £29.00 | 6 months | |
Foundation Years Clinical Cases Database | £39.00 | 12 months |
Authors
SP Harger
Department of Clinical Biochemistry
The Ipswich Hospital
Suffolk IP4 5PD
HD Brooks
Department of Clinical Biochemistry
The Ipswich Hospital
Suffolk IP4 5PD
PJ Twomey (Corresponding author)
Department of Clinical Biochemistry
The Ipswich Hospital
Suffolk IP4 5PD
ptwomey@nhs.net
References
1. Bilezikian JP, Brandi ML, Rubin M, Silverberg SJ. Primary hyperparathyroidism: new concepts in clinical, densitometric and biochemical features. J Intern Med, 2005, 257(1):6-17.
2. Taniegra ED. Hyperparathyroidism. Am Fam Physician, 2004, 69(2):333-339.
3. Marx SJ. Hyperparathyroid and Hypoparathyroid disorders. NEJM, 2000, 343(25):1863-1875.
4. Jones BJ, Twomey PJ. Requesting patterns for serum calcium concentration in patients on long-term lithium therapy. IJCP, 2009, 63:170-172.
5. Kearns AE, Thompson GB. Medical and Surgical Management of Hyperparathyroidism. Mayo Clin Proc, 2002, 77(3):87-91.
6. Bilezikian JP, Potts JT, Fuleihan GE, et al. Summary Statement from a Workshop on Asymptomatic Primary Hyperparathyroidism: A Perspective for the 21st Century. J Clin Endocrinol Metab, 2002, 87(12):5353-5361.
7. Insogna KL, Mitnick ME, Stewart AF, et al. Sensitivity of the parathyroid hormone-1, 25-dihydroxyvitamin D axis to variations in calcium intake in patients with primary hyperparathyroidism. NEJM, 1985, 313(18):1126-1130.
8. Rubin MA, Lee KH, McMahon DJ, Silverberg SJ. Raloxifene lowers serum calcium and markers of bone turnover in post-menopausal women with primary hyperparathyroidism. J Clin Endocrinol Metab, 2003, 88(3): 1174-1178.
9. Reasner CA, Stone MD, Hosking DJ, et al. Acute changes in calcium homeostasis during treatment of primary hyperparathyroidism with risedronate. J Clin Endocrinol Metab, 1993, 77(4):1067-1071.
10. NICE Technology Appraisal TA117. Cinacalcet for the treatment of secondary hyperparathyroidism in patients with end-stage renal disease on maintenance dialysis therapy, (2007).
11. Silverberg SJ, Bilezikian JP, Bone HG, et al. Therapeutic Controversies in Primary Hyperparathyroidism. J Clin Endocrinol Metab, 1999, 84(7):2275-2285.
12. Wermers RA, Khosla S, Atkinson AJ et al; Survival after diagnosis of hyperparathyroidism: a population-based study. Am J Med, 1998, 104(2):115-22.
Disclaimers
Conflict Of Interest
The Journal requires that authors disclose any potential conflict of interest that they may have. This is clearly stated in the Journal’s published “Guidelines for Authors”. The Journal follows the Guidelines against Conflict of Interest published in the Uniform Requirements for Manuscripts Submitted to Biomedical Journals (http://www.icmje.org/urm_full.pdf).
Financial Statement
The authors of this article have not been paid. The Journal is financed by subscriptions and advertising. The Journal does not receive money from any other sources. The decision to accept or refuse this article for publication was free from financial considerations and was solely the responsibility of the Editorial Panel and Editor-in-Chief.
Patient Consent statement
All pictures and investigations shown in this article are shown with the patients’ consent. We require Authors to maintain patients’ anonymity and to obtain consent to report investigations and pictures involving human subjects when anonymity may be compromised. The Journal follows the Guidelines of the Uniform Requirements for Manuscripts (http://www.icmje.org/urm_full.pdf). The Journal requires in its Guidelines for Authors a statement from Authors that “the subject gave informed consent”.
Animal & Human Rights
When reporting experiments on human subjects, the Journal requires authors to indicate whether the procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the HelsinkiDeclaration of 1975, as revised in 2008.
About the Clinical Cases Database
The Foundation Years Clinical Cases Database is a selection of 600 peer-reviewed clinical cases in the field of patient safety and clinical practice, specifically focused on the clinical information needs of junior doctors, based around the Foundation Year Curriculum programme (MMC). The cases have been chosen to align with the Foundation Year Curriculum.
The database is fully searchable, or can be browsed by medical specialty. Abstracts can be read free of charge, however a subscription is required in order to read the complete cases.