Clinical Case Database / Category: Patient Management

Convulsion/seizure in pediatric populations: a common presentation but a rare outcome

Publication details

AK Badrul, N Carmen, K Mamadou, MC Pilar
Foundation Years Journal, volume 7, issue 8, p.6 (123Doc Education, London, August 2013)

Abstract

Autism is a condition characterized by impaired cognitive and social skills associated with compromised immune function. A 6 year old girl presented to us with impaired cognitive and social skills associated with compromised immune function leading to suffer from recurrent chest infection, seizure, intolerance to food and various chemical products. This poor little girl has had completed the vaccine regime as per immunization calendar in Spain. She has been suffering from the symptoms and signs which fulfill the criteria for the diagnosis of autism and obviously, she has been exposed to aluminium (vaccines and/or environmental source) and acetaminophen to control fever and pain as she suffered from recurrent infection. The most important fact is that the test for toxic elements in her hair has shown significantly elevated level of aluminium.

Access the Clinical Cases Database

A subscription is required to read the full article. Please subscribe using one of the options below.

Authors

AK Badrul

-

N Carmen

-

K Mamadou

-

MC Pilar

-

References

1. Stephanie Seneff, Robert M. Davidson and Jingjing Liu. Empirical data confirm Autism Symptoms related to Aluminum and acetaminophen exposure. Entropy 2012, 14, 2227-2253; doi: 10.3390/e14112227.
2. L Tomljenovic, C A Shaw. Mechanism of aluminum adjuvant toxicity and autoimmunity in pediatric populations. Lupus February 1, 2012, 21: 118-120.
3. Theoharides, T. C.; Zang, B. Hypothesis: Neuro-inflammation, blood-brain barrier, seizures and autism. J.Neuroinflamm. 2011, 8, 168.
4. Pogue, A. I. et al. Characterization of an NF-JB-regulated, miRNA-146amediated down-regulation of complement factor H (CHF) in metal-sulfatestressed human brain cells. J. Inorg. Biochem. 2009, 103, 1591-1595.
5. Pogh, A.I. et al. Metal-sulfate induced generation of ROS in human brain cells: Detection using an isomeric mixture of 5- and 6- carboxy- 2´, 7´- dichlorofluoresce in diacetate (carboxy-DCFDA) as a cell permeant tracer. Intl. J. Mol. Sci. 2012, 13, 9615-9626.
6. Frustaci, A. et al. Oxidative stress-related biomarkers in autism: Systemic review and meta-analysis. Free Radic. Biol. Med. 2012, 122, 1207-1213.

Disclaimers

Conflict Of Interest

The Journal requires that authors disclose any potential conflict of interest that they may have. This is clearly stated in the Journal’s published “Guidelines for Authors”. The Journal follows the Guidelines against Conflict of Interest published in the Uniform Requirements for Manuscripts Submitted to Biomedical Journals (http://www.icmje.org/urm_full.pdf).

Financial Statement

The authors of this article have not been paid. The Journal is financed by subscriptions and advertising. The Journal does not receive money from any other sources. The decision to accept or refuse this article for publication was free from financial considerations and was solely the responsibility of the Editorial Panel and Editor-in-Chief.

Patient Consent statement

All pictures and investigations shown in this article are shown with the patients’ consent. We require Authors to maintain patients’ anonymity and to obtain consent to report investigations and pictures involving human subjects when anonymity may be compromised. The Journal follows the Guidelines of the Uniform Requirements for Manuscripts (http://www.icmje.org/urm_full.pdf). The Journal requires in its Guidelines for Authors a statement from Authors that “the subject gave informed consent”.

Animal & Human Rights

When reporting experiments on human subjects, the Journal requires authors to indicate whether the procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the HelsinkiDeclaration of 1975, as revised in 2008.

About the Clinical Cases Database

T​he Foundation Years Clinical Cases Database is​ a selection of 600 peer-reviewed clinical cases in the field of patient safety and clinical practice, specifically focused on the clinical information needs of junior doctors, based around the Foundation Year Curriculum programme (MMC). The cases have been chosen to align with the Foundation Year Curriculum.

The database is fully searchable, or can be browsed by medical specialty. Abstracts can be read free of charge, however a subscription is required in order to read the complete cases.