Clinical Case Database / Category: Patient Management
Carcinoid tumours
Publication details
Burhan Khan, Asad Ali Khan, Majid Mushtaq
Foundation Years Journal, volume 4, issue 9, p.16 (123Doc Education, London, December 2010)
Abstract
Carcinoid tumours are slow-growing neuroendocrine neoplasms that often are indolent and may not become clinically apparent unless develops metastases or carcinoid syndrome. As they originate from neuroendocrine cells, they have secretory properties and may frequently present with hypersecretory syndromes. Carcinoid syndrome usually manifests once liver metastases are present, secreting hormones directly into the systemic circulation. Overall incidence is estimated to be 2–3 cases per 100,000 people annually, but recent evidence suggests the incidence is steadily increasing. Although the disease was thought to be relatively benign, it is now considered to be one of increasing malignancy. They can present in a myriad of ways and at times present a diagnostic challenge. The choice of treatments depends on the symptoms, stage of the disease, degree of uptake of radionuclide and histological features of the tumour.
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Authors
Burhan Khan
Specialist Registrar Respiratory & General Medicine
Darent Valley Hospital
Kent DA2 8DA
Asad Ali Khan
Speciality Doctor Gastroenterology
Grantham & District General Hospital
Grantham NG31 8DG
Majid Mushtaq
Consultant Physician & Clinical Director
Darent Valley Hospital
Kent DA2 8DA
References
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2. Feldman JM, O'Dorisio TM. (1986) Role of neuropeptides and serotonin in the diagnosis of carcinoid tumors. Am J Med, 81:Suppl 6B: 41–48.
3. Namwongprom S, Wong FC, Tateishi u, et al. (2008) Correlation of chromogranin A levels and somatostatin receptor scintigraphy findings in the evaluation of metastases in carcinoid tumors. Ann Nucl Med, 22(4):237–243.
4. Krenning EP, Kwekkeboom DJ, Oei HY, et al. (1994) Somatostatin-receptor scintigraphy in gastroenteropancreatic tumors: an overview of European results. Ann N Y Acad Sci, 733: 416–424.
5. Kulke MH, Mayer RJ. (1999) Carcinoid tumors. N Eng J Med, 340: 858–868.
6. Caplin ME, Buscombe JR, Hilson AJ, et al. (1998) Carcinoid tumour. Lancet, 352: 799–805.
7. Metz DC, Jensen RT. (2003) Endocrine tumours of the gastrointestinal tract. In AK Rustgi, JM Crawford (eds) Gastrointestinal Cancers. Edinburgh: Saunders: 681–720.
8. Bushnell D. (2009) Treatment of metastatic carcinoid tumors with radiolabelled biological molecules. J Natl Compr Canc Netw, 7: 760–764.
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The Foundation Years Clinical Cases Database is a selection of 600 peer-reviewed clinical cases in the field of patient safety and clinical practice, specifically focused on the clinical information needs of junior doctors, based around the Foundation Year Curriculum programme (MMC). The cases have been chosen to align with the Foundation Year Curriculum.
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