Clinical Case Database / Category: Patient Management
Adult-onset Still's disease
Publication details
Dominic Nee, Alastair Hepburn, Todd Leckie
Foundation Years Journal, volume 9, issue 10, p.16 (123Doc Education, London, November 2015)
Abstract
Adult-onset Still's disease (AOSD) is a rare systemic inflammatory disorder of unknown aetiology, characterised by daily spiking fevers, arthritis, an evanescent macular or maculopapular rash and an acute-phase response secondary to the production of pro-inflammatory cytokines. Here we described the case of a young adult presenting acutely with this syndrome, complicated by myopericarditis.
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Authors
Dominic Nee
FY2 in Medicine
Worthing Hospital, Lyndhurst Road, Worthing, BN11 2DH
dominic.nee@wsht.nhs.uk
Alastair Hepburn (Corresponding author)
Consultant Rheumatologist
Worthing Hospital, Lyndhurst Road, Worthing, BN11 2DH
alnhepburn@doctors.org.uk
Todd Leckie
FY1 in Medicine
Worthing Hospital, Lyndhurst Road, Worthing, BN11 2DH
todd.leckie@nhs.net
References
1. Magadur-Joly G, Billaud E, Barrier JH, Pennec YL, Masson C, Renou P, et al. Epidemiology of adult Still's disease: estimate of the incidence by a retrospective study in west France. Ann Rheum Dis. 1995 Jul;54(7):587–90.
2. Evensen KJ, Nossent HC. Epidemiology and outcome of adult-onset Still's disease in Northern Norway. Scand J Rheumatol. 2006 Feb;35(1):48–51.
3. Hot A, Toh M-L, Coppéré B, Perard L, Madoux MHG, Mausservey C, et al. Reactive hemophagocytic syndrome in adult-onset Still disease: clinical features and long-term outcome: a case-control study of 8 patients. Medicine (Baltimore). 2010 Jan;89(1):37–46.
4. Yamaguchi M, Ohta A, Tsunematsu T, Kasukawa R, Mizushima Y, Kashiwagi H, et al. Preliminary criteria for classification of adult Still's disease. J Rheumatol. 1992 Mar;19(3):424–30.
5. Masson C, Le Loet X, Liote F, Dubost JJ, Boissier MC, Perroux-Goumy L, et al. Comparative study of 6 types of criteria in adult Still's disease. J Rheumatol. 1996 Mar;23(3):495–7.
6. Ohta A, Yamaguchi M, Tsunematsu T, Kasukawa R, Mizushima H, Kashiwagi H, et al. Adult Still's disease: a multicenter survey of Japanese patients. J Rheumatol. 1990 Aug;17(8):1058–63.
7. Akritidis N, Giannakakis I, Giouglis T. Ferritin levels and response to treatment in patients with Adult Still's disease. J Rheumatol. 1996 Jan;23(1):201–2.
8. Gerfaud-Valentin M, Maucort-Boulch D, Hot A, Iwaz J, Ninet J, Durieu I, et al. Adult-onset still disease: manifestations, treatment, outcome, and prognostic factors in 57 patients. Medicine (Baltimore). 2014 Mar;93(2):91–9.
9. Durack DT, Street AC. Fever of unknown origin--reexamined and redefined. Curr Clin Top Infect Dis. 1991;11:35–51.
10. Gerfaud-Valentin M, Jamilloux Y, Iwaz J, Sève P. Adult-onset Still's disease. Autoimmun Rev. 2014 Jul;13(7):708–22.
11. Vanderschueren S, Eyckmans T, De Munter P, Knockaert D. Mortality in patients presenting with fever of unknown origin. Acta Clin Belg. 2014 Feb;69(1):12–6.
12. Kouijzer IJE, Bleeker-Rovers CP, Oyen WJG. FDG-PET in fever of unknown origin. Semin Nucl Med. 2013 Sep;43(5):333–9.
13. Laskari K, Tzioufas AG, Moutsopoulos HM. Efficacy and long-term follow-up of IL-1R inhibitor anakinra in adults with Still's disease: a case-series study. Arthritis Res Ther. 2011;13(3):R91.
14. Meijvis SCA, Endeman H, Geers ABM, Borg EJ ter. Extremely high serum ferritin levels as diagnostic tool in adult-onset Still's disease. Neth J Med. 2007 Jun;65(6):212–4.
15. Chakravarty K, McDonald H, Pullar T, Taggart A, Chalmers R, Oliver S, et al. BSR/BHPR guideline for disease-modifying anti-rheumatic drug (DMARD) therapy in consultation with the British Association of Dermatologists. Rheumatol Oxf Engl. 2008 Jun;47(6):924–5.
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