Clinical Case Database / Category: Patient Management

Adrenal Masses: The Diagnosis and Management of Cushing's Disease

Publication details

K Kanesalingam, D van Dellen, T Augustine, JRE Davis
Foundation Years Journal, volume 6, issue 7, p.55 (123Doc Education, London, July 2012)


The diagnosis of Cushing's syndrome is often missed due to its subtle clinical signs and symptoms. This case highlights the diagnosis of Cushing's syndrome focusing on the management and treatment of pituitary-dependent Cushing's disease.

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K Kanesalingam

Department of Transplant and Endocrine surgery

D van Dellen

Department of Transplant and Endocrine surgery

T Augustine

Department of Transplant and Endocrine surgery

JRE Davis

Department of Endocrinology
Central Manchester University Hospitals Foundation Trust,
Manchester Royal Infirmary, UK, and Faculty of Medical and Human Sciences,
University of Manchester, UK.


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2. Boscaro M, Barzon L, Fallo F, et al. Cushing's syndrome. Lancet 2001;357:783–91.
3. Nieman LK, Biller BM, Findling JW, Newell-Price J, Savage MO, Stewart PM, Montori VM. J Clin Endocrinol Metab. The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline.2008; May;93(5):1526-40. Epub 2008 Mar 11.
4. Klibanski A, Zervas N. Diagnosis and management of hormone-secreting pituitary adenomas. N Engl J Med 1991;324:822–31
5. Hammer GD, Tyrrell JB, Lamborn KR, et al. Transsphenoidal microsurgery for Cushing's disease: initial outcome and long-term results. J Clin Endocrinol Metab 2004;89:6348–57
6. Jenkins PJ, Trainer PJ, Plowman PN, Shand WS. Grossman AB, Wass JAH, Besser GM. The role of prophylactic pituitary radiotherapy in the long-term outcome after adrenalectomy for Cushing's disease. J. Clin. Endocrinol. Metab. 1994:79; 165-171.


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About the Clinical Cases Database

T​he Foundation Years Clinical Cases Database is​ a selection of 600 peer-reviewed clinical cases in the field of patient safety and clinical practice, specifically focused on the clinical information needs of junior doctors, based around the Foundation Year Curriculum programme (MMC). The cases have been chosen to align with the Foundation Year Curriculum.

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