Clinical Case Database / Category: Patient Management
A case of mixed warm and cold autoimmune haemolytic anaemia
Publication details
Dr Angela S Clarke, CMT1, Dr Jonathan O Cullis
Foundation Years Journal, volume 9, issue 3, p.6 (123Doc Education, London, March 2015)
Abstract
Anaemia is a common finding in patients admitted to hospital and results from either failure of red cell production, or from increased red cell destruction or loss. We present a rare case of mixed cold and warm autoimmune haemolytic anaemia. The patient's presentation, initial findings and more specialised investigations are discussed, along with management of the case and complexities of the diagnosis.
Access the Clinical Cases Database
A subscription is required to read the full article. Please subscribe using one of the options below.
| Product | Price | Subscription | |
|---|---|---|---|
| Foundation Years Clinical Cases Database | £29.00 | 6 months | |
| Foundation Years Clinical Cases Database | £39.00 | 12 months |
Authors
Dr Angela S Clarke, CMT1
Salisbury NHS Foundation Trust
Salisbury, Wiltshire, SP2 8BJ
angela.clarke@salisbury.nhs.uk
Dr Jonathan O Cullis (Corresponding author)
Consultant Haematologist
Salisbury NHS Foundation Trust, Salisbury, Wiltshire, SP2 8BJ
jonathan.cullis@salisbury.nhs.uk
References
1. Crowther M, Chan YLT, Garbett IK , et al. Evidence-based focused review of the treatment of idiopathic warm immune hemolytic anemia in adults. Blood 2011, 118:4036-40.
2. Lechner K & Jäger U. How I treat autoimmune hemolytic anemias in adults. Blood 2010, 116:1831-8
3. Zanella A & Barcellini W. Treatment of autoimmune hemolytic anemias. Haematologica 2014, 99:1547-54.
4. Swiecicki PL, Hegerova LT & Gertz MA. Cold agglutinin disease. Blood 2013, 122:1114-21.
5. Berentsen S. How I treat cold agglutinin disease. Brit J Haematol 2011, 153:309-17.
6. Morselli M, Luppi M, Potenza L et al. Mixed warm and cold autoimmune hemolytic anemia: complete recovery after 2 courses of rituximab treatment. Blood 2002, 99:3478-9.
7. Webster D, Ritchie B & Mant MJ. Prompt response to rituximab of severe hemolytic anemia with both cold and warm autoantibodies. Am J Hematol 2004, 75:258-9.
8. Gupta S, Szersen A, Nakhl F et al. Severe refractory autoimmune hemolytic anemia with both warm and cold autoantibodies that responded to a single cycle of rituximab: a case report. J Med Case Rep 2011, 5:156-60.
9. Montagnani S, Tuccori M, Lombardi G et al. Autoimmune haemolytic anaemia following MF59-adjuvanted influenza vaccine administration: a report of two cases. Ann Pharmacother 2011, 45:e8.
10. Shlamovitz GZ & Johar S. A case of Evans' syndrome following influenza vaccine. J Emerg Med 2013, 44:e149-51.
11. Shizuma T. Autoimmune hemolytic anemia following influenza virus infection or administration of influenza vaccine. J Blood Disorders Transf 2014, 5:200.
Disclaimers
Conflict Of Interest
The Journal requires that authors disclose any potential conflict of interest that they may have. This is clearly stated in the Journal’s published “Guidelines for Authors”. The Journal follows the Guidelines against Conflict of Interest published in the Uniform Requirements for Manuscripts Submitted to Biomedical Journals (http://www.icmje.org/urm_full.pdf).
Financial Statement
The authors of this article have not been paid. The Journal is financed by subscriptions and advertising. The Journal does not receive money from any other sources. The decision to accept or refuse this article for publication was free from financial considerations and was solely the responsibility of the Editorial Panel and Editor-in-Chief.
Patient Consent statement
All pictures and investigations shown in this article are shown with the patients’ consent. We require Authors to maintain patients’ anonymity and to obtain consent to report investigations and pictures involving human subjects when anonymity may be compromised. The Journal follows the Guidelines of the Uniform Requirements for Manuscripts (http://www.icmje.org/urm_full.pdf). The Journal requires in its Guidelines for Authors a statement from Authors that “the subject gave informed consent”.
Animal & Human Rights
When reporting experiments on human subjects, the Journal requires authors to indicate whether the procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the HelsinkiDeclaration of 1975, as revised in 2008.
About the Clinical Cases Database
The Foundation Years Clinical Cases Database is a selection of 600 peer-reviewed clinical cases in the field of patient safety and clinical practice, specifically focused on the clinical information needs of junior doctors, based around the Foundation Year Curriculum programme (MMC). The cases have been chosen to align with the Foundation Year Curriculum.
The database is fully searchable, or can be browsed by medical specialty. Abstracts can be read free of charge, however a subscription is required in order to read the complete cases.